Every year as mosquito season arrives, so does West Nile virus, causing fever in thousands of people nationwide and life-threatening brain infections in an unlucky few. About half the people who survive that infection – West Nile encephalitis – are left with permanent neurological deficits such as memory loss. New research shows that these long-term neurological problems may be due…
Scientists at UMass Medical School have performed the first CRISPR/Cas9 screen to discover human proteins that Zika virus needs for replication. This work, led by Abraham Brass, MD, PhD, assistant professor in microbiology & physiological systems, reveals new leads that may be useful for halting Zika, dengue and other emerging viral infections. “These genetic screens give us our first look at…
A federal biosafety and ethics panel on Tuesday unanimously approved the first study in patients of the genome-editing technology CRISPR/Cas9, in an experiment that would use CRISPR to create genetically-altered immune cells to attack three kinds of cancer. The experiment, proposed by scientists at the University of Pennsylvania, still needs the approval of the medical centers where it would be…
People with cancer are often told by their doctors approximately how long they have to live, and how well they will respond to treatments, but what if there were a way to improve the accuracy of doctors’ predictions? A new method developed by UCLA scientists could eventually lead to a way to do just that, using data about patients’ genetic…
Loyola University Chicago researchers are among the co-authors of a groundbreaking study that found humans have a higher metabolism rate than closely related primates, which enabled humans to evolve larger brains. The study, published in the journal Nature, found that humans also have a higher percentage of body fat, providing the energy reserves to fuel their faster metabolism. The findings…
High-fructose corn syrup is a grocery store staple, an inexpensive additive found in everything from soda to spaghetti sauce. We already know that diets heavy in it are a likely road to obesity and diabetes, but according to a new study funded by the National Institutes of Health, fructose may also be doing widespread damage to our genes. The study…