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Penn Scientists Use CRISPR for First Time to Correct Clotting in Newborn and Adult Mice

CRISPR/Cas9, a powerful genome editing tool, is showing promise for efficient correction of disease-causing mutations. For the first time, researchers from the Perelman School of Medicine at the University of Pennsylvania have developed a dual gene therapy approach to deliver key components of a CRISPR/Cas9-mediated gene targeting system to mice to treat hemophilia B. This disorder is also called factor…

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Our Brains Have A Basic Algorithm That Enables Our Intelligence, Scientists Say

Our brains have a basic algorithm that enables us to not just recognize a traditional Thanksgiving meal, but the intelligence to ponder the broader implications of a bountiful harvest as well as good family and friends. “A relatively simple mathematical logic underlies our complex brain computations,” said Dr. Joe Z. Tsien, neuroscientist at the Medical College of Georgia at Augusta University,…

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How Mammary Glands Appeared In The Course Of Evolution

A joint team of geneticists from the University of Geneva (UNIGE) and the Swiss Federal Institute of Technology in Lausanne (EPFL), Switzerland, demonstrated that the emergence of mammary glands in placental mammals and marsupials results from recycling certain ‘architect’ genes. The latter, known as Hox genes, are responsible for coordinating the formation of the organs and limbs during the embryonic…

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Unlocking Big Genetic Data Sets

The same algorithms that personalize movie recommendations and extract topics from oceans of text could bring doctors closer to diagnosing, treating and preventing disease on the basis of an individual’s unique genetic profile. In a study to be published Monday, Nov. 7 in Nature Genetics, researchers at Columbia and Princeton universities describe a new machine-learning algorithm for scanning massive genetic…

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