Biomedical research is often slow and incremental, but it can take a leap when someone uncovers a hidden connection. Today, one group of researchers is launching a crowdsourcing initiative to pave the way, by harnessing the efforts of lay volunteers who will scan papers for key terms to help create a powerful searchable database. This crowdsourcing curation campaign, dubbed Mark2Cure,…
The Genotype-Tissue Expression (GTEx) project consortia, which includes scientists from the Centre for Genomic Regulation (CRG) in Barcelona, have now published their results from their first pilot study in three Science papers. These finding will contribute to a better understanding of genomic variation and give us new clues about disease susceptibility. The GTEx resource is being developed in part to…
Researchers at Caltech have discovered how an abundant class of RNA genes, called long non-coding RNAs (lncRNAs, pronounced link RNAs) can regulate key genes. By studying an important lncRNA, called Xist, the scientists identified how this RNA gathers a group of proteins and ultimately prevents women from having an extra functional X-chromosome–a condition in female embryos that leads to death…
Excerpt: “In March, a rumor surfaced in the scientific community that was intriguing, and perhaps a bit chilling: According to those in the know, researchers in China had successfully edited the genomes of human embryos, altering their DNA in a way never accomplished in our own species. MIT Technology Review reported on the murmurings that someone had altered the germ line —…
A special section of commentaries and reflections on epigenetic inheritance has been published in the International Journal of Epidemiology, centered on the reprint of the 1989 article “Inheritance of Acquired Epigenetic Variations” by Eva Jablonka and Marion Lamb. ISG faculty members Aaron Panofsky and Hannah Landecker both contributed invited commentaries to the issue, which is now available in advance online…
Big data: It’s a term we read and hear about often, but is hard to grasp. Computer scientists at Washington University in St. Louis’ School of Engineering & Applied Science tackled some big data about an important protein and discovered its connection in human history as well as clues about its role in complex neurological diseases. Through a novel method…