Genomes

Genetics Of Type 2 Diabetes Revealed In Unprecedented Detail

A comprehensive investigation of the underlying genetic architecture of type 2 diabetes has unveiled the most detailed look at the genetic differences that heighten a person’s risk for disease development. The findings, published today in the journal Nature by an international team of more than 300 scientists led by the University of Oxford, the Broad Institute, and the University of…

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How Did Birds Get Their Wings? Bacteria May Provide a Clue, Say Scientists

New research from an international team of evolutionary biologists, led by the University of Oxford, has used bacteria to show that acquiring duplicate copies of genes can provide a ‘template’ allowing organisms to develop new attributes from redundant copies of existing genes. The researchers allowed 380 populations of Pseudomonas aeruginosa bacteria to evolve novel metabolic traits such as the ability…

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Analysis of Dog Genome Will Provide Insight Into Human Disease

New research published today in PLOS ONE reveals an improved annotation of microRNAs in the dog genome to further understand its biological role. Providing a platform for future studies into biomedicine, evolution and the domestication of important animals including dogs, cows, horses and pigs. This discovery provides a significant opportunity not only to enhance our understanding of how miRNAs regulate…

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Diets Heavy In Fructose Damage Genes Related To Memory And Metabolism, Says Study

High-fructose corn syrup is a grocery store staple, an inexpensive additive found in everything from soda to spaghetti sauce. We already know that diets heavy in it are a likely road to obesity and diabetes, but according to a new study funded by the National Institutes of Health, fructose may also be doing widespread damage to our genes. The study…

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Western Lowland Gorilla Genome Mapped with New Level of Accuracy

The genome of the Western lowland gorilla (Gorilla gorilla ssp. gorilla) has been sequenced at a high level of quality beginning to approach that of the human genome, says a team of scientists led by Prof. Evan Eichler from the University of Washington. Prof. Eichler and his colleagues used long-read sequencing technology, along with a unique combination of algorithms, to…

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Scientists Produce Map of Neanderthal, Denisovan Ancestry in Present-Day Humans

Dr. David Reich from Harvard Medical School and his colleagues have produced a world map of Denisovan and Neanderthal ancestry in 120 diverse populations. Their analysis proposes that Denisovan admixture into humans occurred about 100 generations after Neanderthal admixture.  Dr. Reich and co-authors collected their data by comparing known Neanderthal and Denisovan gene sequences across more than 250 genomes from…

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