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Maris Laan – Biomarker Studies for Male and Female Reproductive Health

Maris Laan, Ph.D., Professor, Institute of Molecular and Cell Biology, Biology and Geography, University of Tartu, Estonia will present her current research in a lecture titled, “Biomarker Studies for Male and Female Reproductive Health” as part of the David Geffen School of Medicine at UCLA Department of Human Genetics Speaker Series.

Abstract: The current focus in our research team at the University of Tartu, Estonia is to find novel genetic and serum-based biomarkers relevant to the timely evaluation of male and female reproductive health, and the course of pregnancy. So far, aiming to identify genetic determinants of female and male reproductive disorders, hundreds of DNA variants in pre-selected candidate genes have been studied, but only few exhibit potential diagnostic value in reproductive biomedicine1. Similarly to genetic studies, biochemical biomarker research in pregnancy complications has been mostly based on pre-selected serum/plasma markers. In the seminar I discuss our discovery of the FSHB -211 G/T polymorphism as the main genetic determinant of male serum FSH and its effect on downstream male reproductive parameters and fertility2, as well as our investigations of placental transcriptome dynamics3 to pinpoint novel potential biomarkers for early (recurrent miscarriage, ectopic pregnancy) and late (preeclampsia, gestational diabetes, affected fetal growth) pregnancy complications.

Monday, June 10, 2013
11:00 AM - 12:00 PM
Los Angeles, CA, Gonda Center Conference Room – 1357

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