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Y Gene Not Necessary for Assisted Reproduction of Mice

manoa-jabsom-mice-1The Y chromosome is a symbol of maleness, present only in males and encoding genes important for male reproduction. But a new study has shown that live mouse progeny can be generated with assisted reproduction using germ cells from males which do not have any Y chromosome genes. This discovery adds a new light to discussions on Y chromosome gene function and evolution. It supports the hypothesis that Y chromosome genes can be replaced by that encoded on other chromosomes. “Most of the mouse Y chromosome genes are necessary for development of mature sperm and normal fertilization, both in mice and in humans,” Ward said. “However, when it comes to assisted reproduction, we have now shown that in the mouse the Y chromosome contribution is not necessary.”

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