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Flatworms Could Replace Mammals for Some Toxicology Tests

Scientists at UC San Diego have discovered that planarians, commonly used in high-school biology labs to study regeneration and the primitive nervous system, are actually quite sophisticated when it comes to modeling the response of the developing human nervous system to potentially toxic chemicals. The researchers published their findings in the current issue of the journal Toxicological Sciences. “Because planarians have unique features such as a brain of intermediate complexity, a short regeneration time and offer the possibility of studying adults and developing worms in parallel, they make a good complementary system to existing animal models for studying developmental neurotoxicity,” said Eva-Maria Schoetz Collins, an assistant professor of biology and physics who headed the research group. “Using such alternative animal models will not only reduce costs, but will also significantly reduce the number of laboratory mammals used in toxicology tests.”

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